Stem cells in regenerative and molecular medicine
Prof. Michele De Luca, Prof. Graziella Pellegrini, Prof. Rossella Manfredini (Dep. of Life Sciences, Unimore)
3 CFU
Schedule: September-October 2021
Programme:
1. Stem cell Biology
Biology of embryonic stem cells.
Regulation of self-renewal of stem cells.
Genetics and epigenic of induced pluripotency.
Biology of somatic stem cells such as: epithelial (e.g. epidermis, ocular surface, intestine), mesenchymal, neural, muscular.
Regenerative and translational medicine concepts.
Clinical applications of somatic stem cells. Potential clinical applications of pluripotent stem cells.
2. Regulation of advanced therapies Introduction to Regenerative Medicine in the European context.
European pharmaceutical rules applied to advanced therapy products.
GMP bases or Good Manufacturing Standards and quality system logics.
Examples of Cell Therapy, Tissue Engineering and Gene Therapy.
Elements of nanotechnology in biology.
Notes on pharmaceutical trials with Advanced Therapies.
3. Hematopoietic stem cells and molecular medicine
Biology of Hematopoietic stem cells
Transcriptional regulation of hematopoietic differentiation
Clinical applications of Hematopoietic stem cells
Hematopoietic stem cells in leukemia and myeloproliferative diseases
Molecular and functional characterization of Hematopoietic stem cells
Transcriptome analysis in bulk and at single cell level
Target therapy on leukemic stem cells