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Stem cells in regenerative and molecular medicine

Prof. Michele De Luca, Prof. Graziella Pellegrini, Prof. Rossella Manfredini (Dep. of Life Sciences, Unimore)


Schedule: September-October 2022


1. Stem cell Biology

Biology of embryonic stem cells.

Regulation of self-renewal of stem cells.

Genetics and epigenic of induced pluripotency.

Biology of somatic stem cells such as: epithelial (e.g. epidermis, ocular surface, intestine), mesenchymal, neural, muscular.

Regenerative and translational medicine concepts.

Clinical applications of somatic stem cells. Potential clinical applications of pluripotent stem cells.


2. Regulation of advanced therapies Introduction to Regenerative Medicine in the European context.

European pharmaceutical rules applied to advanced therapy products.

GMP bases or Good Manufacturing Standards and quality system logics.

Examples of Cell Therapy, Tissue Engineering and Gene Therapy.

Elements of nanotechnology in biology.

Notes on pharmaceutical trials with Advanced Therapies.


3. Hematopoietic stem cells and molecular medicine

Biology of Hematopoietic stem cells

Transcriptional regulation of hematopoietic differentiation

Clinical applications of Hematopoietic stem cells

Hematopoietic stem cells in leukemia and myeloproliferative diseases

Molecular and functional characterization of Hematopoietic stem cells

Transcriptome analysis in bulk and at single cell level

Target therapy on leukemic stem cells