Statistical design of experiments
3 CFU
Schedule: November-December 2021
Programme:
Date | Topic | Hours |
DAY 1 | Part I Lecture: Principles of causation: causal inference, directed acyclic graphs, relation between variables (bias, confounding, effect modification)
Part II Lecture: Overview of epidemiological study designs Group assignment - problem solving
Part III Lecture: Basics of experimental studies Theoretical exercise on types of experiential studies and types of clinical trials |
1h
45min 30min
1h 15min 30min |
DAY 2 | Part I Lecture: Principles of statistical inference Group assignment - statistical vs. clinical inference
Part II Lecture: Sample size and Power calculation Practical exercise on calculating power and sample size for experimental study
Part III Lecture: Choice of adequate statistical test Group assignment - problem solving
Part IV Practical exercise in SPSS or STATA |
1h 15min
30min 15min
45min 30min
45min |
DAY 3 | Part I Lecture: Basics of correlation use and missuse Theoretical exercise correlation
Part II Lecture: Regression basic principles Lecture: Linear regression and multiple linear regression
Part III Practical exercise in SPSS or STATA |
40min 20min
45min 1h 30min
45min |
DAY 4 | Part I Lecture: Logistic regression basic concepts |
30min |
| Lecture: Single and multiple logistic regression | 45min |
Part II Lecture: Logistic regression variable selection and model building Lecture: Logistic regression statistical adjustment interaction and confounding Lecture: Logistic regression diagnostics |
45min 45min
30min | |
Part III Practical exercise in SPSS or STATA |
45min | |
DAY 5 | Part I Lecture: Statistical analysis in experimental design - intention to treat analysis, primary and subgroup analysis |
45min |
| Part II Lecture: analysis of variance (ANOVA) and covariance (ANCOVA) Lecture: repeated measures analysis Lecture: time to event analysis comparing survival curves |
45min 45min 1h |
| Part III Practical exercizes in SPSS or STATA |
45min |
DAY 6 | Presentation and discussion of a protocol for the experimental study assigned in day one | 2h + 2h |