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Statistical design of experiments

3 CFU

Schedule: NMay,31 - June 14, 2021

Programme:

Date

Topic

Hours

DAY 1

Part I

Lecture: Principles of causation: causal inference, directed acyclic graphs, relation between variables (bias, confounding, effect modification)

 

Part II

Lecture: Overview of epidemiological study designs Group assignment - problem solving

 

Part III

Lecture: Basics of experimental studies

Theoretical exercise on types of experiential studies and types of clinical trials

 

1h

 

 

 

45min 30min

 

 

1h 15min 30min

 

DAY 2

Part I

Lecture: Principles of statistical inference

Group assignment - statistical vs. clinical inference

 

Part II

Lecture: Sample size and Power calculation

Practical exercise on calculating power and sample size for experimental study

 

Part III

Lecture: Choice of adequate statistical test Group assignment - problem solving

 

Part IV

Practical exercise in SPSS or STATA

 

1h 15min

 

 

30min 15min

 

 

 

45min 30min

 

 

45min

DAY 3

Part I

Lecture: Basics of correlation – use and missuse Theoretical exercise – correlation

 

Part II

Lecture: Regression – basic principles

Lecture: Linear regression and multiple linear regression

 

Part III

Practical exercise in SPSS or STATA

 

40min 20min

 

 

45min  1h 30min

 

45min

DAY 4

Part I

Lecture: Logistic regression – basic concepts

 

30min

 

Lecture: Single and multiple logistic regression

45min

Part II

Lecture: Logistic regression – variable selection and model building Lecture: Logistic regression – statistical adjustment – interaction and confounding

Lecture: Logistic regression – diagnostics

 

45min 45min

 

30min

Part III

Practical exercise in SPSS or STATA

 

45min

DAY 5

Part I

Lecture: Statistical analysis in experimental design - intention to treat analysis, primary and subgroup analysis

 

45min

 

Part II

Lecture: analysis of variance (ANOVA) and covariance (ANCOVA) Lecture: repeated measures analysis

Lecture: time to event analysis – comparing survival curves

 

45min 45min 1h

 

Part III

Practical exercizes in SPSS or STATA

 

45min

DAY 6

Presentation and discussion of a protocol for the experimental study

assigned in day one

2h + 2h