Reasearch topics
Principal Investigator | Research Topics |
---|---|
Bertacchini Jessika
| MUSCLE-BONE CROSS TALK - Design and Simulation of microfluidic devices capable of recreating the tissue-tissue interface to mimic the microarchitecture of an organ, focused on the muscle-bone interface |
Bianchi Elisa |
MECHANISMS UNDERLYING NORMAL AND LEUKEMIC HEMATOPOIESIS
- Identification of novel molecular players supporting chronic inflammation and fibrosis in myelofibrosis. -Transcriptional control of normal and neoplastic hematopoiesis. |
Bicciato Silvio
| BIOINFORMATICS Ongoing research projects: Integrative analysis of multi-omics data from bulk and single cell high-throughput technologies; Reconstruction of gene regulatory networks in physiological and pathological cell states; Identification of of cellcell interactions and communication from single cell gene expression data; Development of computational methods to model the cellular ecosystem of normal and cancer tissues. |
Bortolotti Carlo Augusto
| DEVELOPMENT OF BIO-(IN)ORGANIC INTERFACES FOR NANOBIOTECHNOLOGICAL APPLICATIONS; ORGANIC BIOELECTRONIC DEVICES FOR HEALTH (SENSORS) AND INVESTIGATION OF BIOLOGIC PROCESSES Design, fabrication and characterization of bio(in)organic interfaces, with a focus on organic electronic devices, for health and life science applications. |
Carnevale Gianluca
| DEVELOPMENTAL BIOLOGY AND MOLECULAR CHARACTERIZATION OF NEURAL CREST-MESENCHYMAL STEM CELLS Immunomodulatory properties of dental pulp stem cells; |
Chiarini Francesca | Nuclear envelope dynamics in epigenetic regulation, chromatin organization and gene regulation Role of nuclear lamins and their interplay with cell structure, function and localization in bone sarcomas Identification of the genetic and biochemical alterations responsible for the pathogenesis and progression of sarcomas and hematological diseases |
De Luca Michele
| MOLECULAR MECHANISMS REGULATING EPITHELIAL STEM CELL RENEWAL AND PROLIFERATION AND EPIDERMAL STEM CELL-MEDIATED CELL AND GENE THERAPY Molecular and functional characterization of human epidermal stem cells; |
Enzo Elena | SINGLE-CELLS MOLECULAR PROFILING OF EPIDERMAL STEM CELL FOR REGENRATIVE APPLICATIONS |
Fanelli Francesca
| COMPUTATIONAL STRUCTURAL BIOLOGY Ongoing projects: |
Imbriano Carol
| TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF TRANSCRIPTION FACTORS IN CELL TRANSFORMATION AND CANCER PROGRESSION The activity of the laboratory is focused on NF-Y, a heterotrimeric transcription factor with a pioneering role in the establishment of transcriptional programs. NF-Y is one of the transcription factors orchestrating oncogenic transcriptional changes, as a result of its activity in the transcription of several genes fundamental in the balance between cell proliferation, diffeentiation and cell death. The research is directed towards investigating the transcriptional activity of NF-Y in cancer cells, in particular the function of NF-Y splice variants generated by alternative splicing events. Through in vitro and in vivo genetic, molecular and cellular biology approaches, the team is shedding light on the role of NF-Y isoforms in cancer phenotype and their possible use as novel biomarkers in patients stratification. Current investigation is focused on splice-switching strategies based on antisense oligonucleotides as therapeutic approach to alter NF-Y splicing and, consequently, inhibit the metastatic potential of cancer cells. |
Losi Lorena
| IDENTIFICATION OF GENETIC AND EPIGENETIC ALTERATIONS TO SEARCH BIOMOLECULAR MARKERS FOR DIAGNOSIS, PROGNOSIS AND SELECTIVE THERAPIES IN NEOPLASIAS Identification of genetic and epigenetic alterations to search biomolecular markers for diagnosis, prognosis and selective therapies in several neoplasias, particularly colorectal and ovarian tumours. |
Luppi Mario
| GENETIC AND IMMUNOLOGIC PATHOGENESIS OF HEMATOLOGIC DISEASES Special areas of research activity: |
Manfredini Rossella
| MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF NORMAL AND CANCER STEM CELLS Identification of the deranged regulatory non coding RNA in Leukemic Stem Cells (LSC) of blood neoplasms (Acute leukemias and myeloproliferative diseases);
|
Marasca Roberto
| GENETIC AND IMMUNOLOGIC PATHOGENESIS OF HEMATOLOGIC DISEASES Special areas of research activity: |
Marigo Valeria
| MOLECULAR BIOLOGY OF RETINAL DEGENERATION The focus of the laboratory is basic and preclinical research on rare diseases affecting vision: retinal degeneration and albinism. Retinal degenerations, specifically Retinitis Pigmentosa and Leber Congenital Amaurosis, are the major cause of incurable blindness during early adulthood and working age. They are neurodegenerative diseases caused by cell death in photoreceptor cells. Retinal degeneration is characterirised by high genetic heterogeneity with more than 100 genes identified and this feature hampers the development of a treatment. The genetic defect has been identified for some of them, however the pathogenetic mechanism causing photoreceptor cell death is still poorly understood and the dieseas represents an unmet medical need. |
Mattioli Anna Vittoria
| CARDIOVASCULAR APPLICATION OF REGENERATIVE MEDICINE Cardiac, muscolar and vascular regeneration: trigger and mecanism |
Norfo Ruggiero | MOLECULAR AND CELLULAR MECHANISMS REGULATING HEMATOPOIETIC STEM CELL BIOLOGY IN MYELOID MALIGNANCIES Identification of the mechanisms of tumorigenesis in haematopoietic stem cells in leukaemia and myeloproliferative neoplasms |
Palumbo Carla
| MUSCLE-BONE CROSS TALK Muscle-bone cross talk and related signaling during bone regeneration. Peripheral neurodegeneration and correlated alterations of the bone-muscle cross-talk Interactions between biophysical energy and biological tissues: use of Pulsed Electro-Magnetic Fields (PEMFs) in neurodegenerative recovery after peripheral lesions HISTO-PHYSIO-PATHOLOGY OF SKELETAL TISSUES AND REGENERATIVE STRATEGIES FOR THE RECOVERY OF OSTEOCHONDRAL LESIONS CAM assay: ethical in ovo model in alternative to animal experimentation/tests PAL-OS® - Scleral Ossicles (SO): development of naturally decellularized new biomaterials in defining novel strategies for regenerative medicine Engineered 3D constructs Interaction between skeletal tissues and biomaterials, for the recovery of locomotor apparatus defects
|
Pellegrini Graziella
| MOLECULAR MECHANISMS REGULATING EPITHELIAL STEM CELL RENEWAL AND PROLIFERATION AND EPITHELIAL STEM CELL-MEDIATED CELL THERAPY Molecular and functional characterization of human epithelial stem cells (epidermis, cornea, conjunctiva, urethra, oral mucosa and airway epithelia); |
Pietrangelo Antonello
| GENETIC AND MOLECULAR BASIS OF IRON DISORDERS Ongoing research projects: |
Quaglino Daniela
| BIOLOGY AND PATHOLOGY OF THE EXTRACELLULAR MATRIX Ongoing research projects:
|
Recchia Alessandra
| GENE TRANSFER AND GENE EDITING Recchias lab is focused on the design, development and validation of gene editing systems for in vitro or in vivo gene correction/engineering. Non viral (plasmid, RNA , ribonucleoparticles transfection/electroporation) or viral (Adeonviral, AAV or lentiviral) delivery of gene editing tools have been approached. Gene editing systems and viral vectors aim to correct rare genetic diseases or to engineer T cells for cancer immunotherapy. |