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Seminar announcement Dr. Stanislas Goriely - Nov. 21, 2016

November 21, 2016, h  14.00

Understanding the role of the RNA-binding protein Tristetraprolin in immune homeostasis

Dr. Stanislas Goriely, MD    (Institute for Medical Immunology,Université Libre de Bruxelles -ULB-, Belgium)

Room L1.3 (Room E), building MO17, Via Campi 213/A

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Different mechanisms may control the duration and intensity of inflammatory processes. Expression of some key pro-inflammatory genes is controlled at the post-transcriptional level by the degradation of their messenger RNA. Presence of AU-rich elements (AREs) in their 3’ untranslated region allows the recruitment of RNA-binding protein (such as tristetraprolin, TTP) and subsequent  destabilization. In macrophages or dendritic cells, TTP acts as a major regulator of RNA degradation and controls the production of major inflammatory cytokines such as TNF or IL-23. We will discuss recent unexpected findings about the role of TTP in the control of skin, lung and gut immune homeostasis.

Stanislas Goriely Biosketch:

He graduated as a Medical doctor in 1999 at the Université Libre de Bruxelles (ULB, Belgium) and then joined the lab of Michel Goldman. He has been appointed FNRS Research Associate in 2007 and is leading a team at the Institute for Medical Immunology (ULB). He has a broad expertise in signaling pathways and transcriptional regulation in the context of innate and adaptive immune responses. The group made several important contributions to the understanding of dendritic cell functions and the regulation of IL-12 family members. Recent works mainly address the role of fundamental molecular mechanisms in the control of inflammation using animal models. Ongoing projects also explore the transcriptional networks involved in memory CD8 T cells formation and the signaling pathways triggered by vaccine adjuvants.