Research topics
Principal Investigator | Research Topics |
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Bertacchini Jessika
| MUSCLE-BONE CROSS TALK - Design and Simulation of microfluidic devices capable of recreating the tissue-tissue interface to mimic the microarchitecture of an organ, focused on the muscle-bone interface |
Bianchi Elisa |
MECHANISMS UNDERLYING NORMAL AND LEUKEMIC HEMATOPOIESIS
- Identification of novel molecular players supporting chronic inflammation and fibrosis in myelofibrosis. -Transcriptional control of normal and neoplastic hematopoiesis. |
Bortolotti Carlo Augusto
| DEVELOPMENT OF BIO-(IN)ORGANIC INTERFACES FOR NANOBIOTECHNOLOGICAL APPLICATIONS; ORGANIC BIOELECTRONIC DEVICES FOR HEALTH (SENSORS) AND INVESTIGATION OF BIOLOGIC PROCESSES Design, fabrication and characterization of bio(in)organic interfaces, with a focus on organic electronic devices, for health and life science applications. |
Carnevale Gianluca
| DEVELOPMENTAL BIOLOGY AND MOLECULAR CHARACTERIZATION OF NEURAL CREST-MESENCHYMAL STEM CELLS Immunomodulatory properties of dental pulp stem cells; |
Cavazza Alessia | THERAPEUTIC GENE EDITING Development of gene editing strategies (including base and prime editing) for the treatment of rare genetic disorders of the hematopoietic system and metabolic diseases |
Chiarini Francesca | NUCLEAR DYNAMICS IN CANCER Nuclear envelope dynamics in epigenetic regulation, chromatin organization and gene regulation |
Corradini Elena | |
De Luca Michele
| MOLECULAR MECHANISMS REGULATING EPITHELIAL STEM CELL RENEWAL AND PROLIFERATION AND EPIDERMAL STEM CELL-MEDIATED CELL AND GENE THERAPY Molecular and functional characterization of human epidermal stem cells; |
Fanelli Francesca
| COMPUTATIONAL STRUCTURAL BIOLOGY Ongoing projects: |
Giuggioli Dilia | |
Grande Alexis | |
Imbriano Carol
| MOLECULAR CANCER GENETICS The activity of the laboratory is focused on NF-Y, a heterotrimeric transcription factor with a pioneering role in the establishment of transcriptional programs. NF-Y regulates several cancer pathways and promotes cancer cell growth and survival, through the transcriptional regulation of genes controlling proliferation, metabolism, differentiation, cell death and invasiveness. The research is directed towards investigating the transcriptional activity of NF-Y in cancer cells, in particular the function of NF-Y splice variants generated by alternative splicing events. Through in vitro and in vivo genetic, molecular and cellular biology approaches, the team is shedding light on: i) the role of NF-Y isoforms produced by alternative splicing in cancer cells and their possible use as novel biomarkers in patients stratification; |
Losi Lorena
| IDENTIFICATION OF GENETIC AND EPIGENETIC ALTERATIONS TO SEARCH BIOMOLECULAR MARKERS IN NEOPLASIAS Identification of genetic and epigenetic alterations to search biomolecular markers for diagnosis, prognosis and selective therapies in several neoplasias, particularly colorectal and ovarian tumours. |
Manfredini Marco | GENETIC AND IMMUNOLOGIC PATHOGENESIS OF INFLAMMATORY SKIN DISEASES Molecular and functional characterization of keratinocytes in different pathologic conditions |
Manfredini Rossella
| MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF NORMAL AND CANCER STEM CELLS Identification of the deranged regulatory non coding RNA in Leukemic Stem Cells (LSC) of blood neoplasms (Acute leukemias and myeloproliferative diseases);
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Marasca Roberto
| GENETIC AND IMMUNOLOGIC PATHOGENESIS OF HEMATOLOGIC DISEASES Special areas of research activity: |
Marconi Alessandra | MOLECULAR CHARACTERIZATION OF STEM CELL NICHE AND PATHOPHYSIOLOGY OF THE SKIN Development of 3D skin models for mimic physiological condition of human skin |
Marigo Valeria
| MOLECULAR BIOLOGY OF RETINAL DEGENERATION basic and preclinical research on rare diseases affecting vision and causing retinal degeneration, i.e. Retinitis Pigmentosa and Leber Congenital Amaourosis |
Palumbo Carla
| MUSCLE-BONE CROSS TALK Muscle-bone cross talk and related signaling during bone regeneration. Peripheral neurodegeneration and correlated alterations of the bone-muscle cross-talk Interactions between biophysical energy and biological tissues: use of Pulsed Electro-Magnetic Fields (PEMFs) in neurodegenerative recovery after peripheral lesions HISTO-PHYSIO-PATHOLOGY OF SKELETAL TISSUES AND REGENERATIVE STRATEGIES FOR THE RECOVERY OF OSTEOCHONDRAL LESIONS CAM assay: ethical in ovo model in alternative to animal experimentation/tests PAL-OS® - Scleral Ossicles (SO): development of naturally decellularized new biomaterials in defining novel strategies for regenerative medicine Engineered 3D constructs Interaction between skeletal tissues and biomaterials, for the recovery of locomotor apparatus defects
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Pellegrini Graziella
| MOLECULAR MECHANISMS REGULATING EPITHELIAL STEM CELL RENEWAL AND PROLIFERATION AND EPITHELIAL STEM CELL-MEDIATED CELL THERAPY Molecular and functional characterization of human epithelial stem cells (epidermis, cornea, conjunctiva, urethra, oral mucosa and airway epithelia); |
Pietrangelo Antonello
| GENETIC AND MOLECULAR BASIS OF IRON DISORDERS Ongoing research projects: |
Quaglino Daniela | BIOLOGY AND PATHOLOGY OF THE EXTRACELLULAR MATRIX Ongoing research projects: |
Recchia Alessandra
| GENE TRANSFER AND GENE EDITING Recchias lab is focused on the design, development and validation of CRISPR gene editing systems for gene correction/engineering. The ongoing research projects are: editing of the TCR of T lymphocytes for cancer immunotherapy, CRISPR correction of laminopathic mutations in patients cells to generate in vitro models to identify biomarkers for Emery-Dreifuss Muscular Dystrophy and unravel pathogenic pathways in Hutchinson-Gilford Progeria; develop non viral systems (VLP and LNP) to deliver CRISPR base editor in engineered retianl cell in vitro. |